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422097

Electrolyte Imbalances Resulting from Phototherapy Use in Neonatal Hyperbilirubinemia in Suez Canal University Hospital’s Neonatal Intensive Care Unit.

Article

Last updated: 27 Apr 2025

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Tags

Clinical Research (Medical)

Abstract

Background: Neonatal hyperbilirubinemia is a very common clinical problem during the neonatal period. It occurs due to excessive formation of unconjugated bilirubin and limited ability of neonatal liver to rapidly clear it from the blood. Phototherapy is one of the most effective ways available in preventing the neurotoxic complications of indirect hyperbilirubinemia, but it can cause unwanted side effects including electrolyte abnormalities. Aim: To estimate serum electrolyte levels in neonates before and after phototherapy and to detect electrolyte imbalances arising due to phototherapy if they ever occurred. Patients and methods: This prospective hospital based observational comparative study was conducted on forty eligible neonates admitted to Suez Canal University Hospital's Neonatal Intensive Care Unit with unconjugated hyperbilirubinemia not associated with any co-morbidity. Results: Differences in serum electrolytes (sodium, potassium, ionized calcium, magnesium) and creatinine levels after different intervals of phototherapy were statistically significant (P value for all electrolytes were <0.001) ; all cases had normal serum electrolyte levels on admission, 45% of them developed hyponatremia, 30% had hypokalemia, 65% encountered hypocalcemia, 32.5% developed hypomagnesemia and 25% of cases had elevated serum creatinine level more than normal after 48 hours or more of phototherapy. There was a statistically significant relationship between gestational age and changes that occurred in serum sodium level after 48 hours or more of phototherapy (P value 0.001). Conclusion: Phototherapy results in remarkable decline in serum bilirubin level together with different effects on serum electrolytes (sodium, potassium, ionized calcium, magnesium) and creatinine. 

DOI

10.21608/scumj.2024.422097

Keywords

Light therapy, Jaundice, electrolyte disturbance

Authors

First Name

Shimaa

Last Name

Abd El-kader

MiddleName

Ragab

Affiliation

Pediatrics and Neonatology Department, Faculty of Medicine, Suez Canal University, Ismailia, Egypt

Email

shimaa.ragab35@yahoo.com

City

-

Orcid

-

First Name

Amina

Last Name

Abdel-Wahab

MiddleName

Mohamed

Affiliation

Pediatrics and Neonatology Department, Faculty of Medicine, Suez Canal University, Ismailia, Egypt

Email

amina_abdelwahab@yahoo.com

City

-

Orcid

-

First Name

Enas

Last Name

El Nagar

MiddleName

F.

Affiliation

Pediatrics and Neonatology Department, Faculty of Medicine, Suez Canal University, Ismailia, Egypt

Email

dr_enas.elngar@yahoo.com

City

-

Orcid

-

First Name

Marwa

Last Name

Ibrahim

MiddleName

Ahmed

Affiliation

Pediatrics and Neonatology Department, Faculty of Medicine, Suez Canal University, Ismailia, Egypt

Email

marwaahmedibrahim@med.suez.edu.eg

City

Ismailia

Orcid

-

Volume

27

Article Issue

8

Related Issue

52240

Issue Date

2024-08-01

Receive Date

2024-04-01

Publish Date

2024-08-01

Page Start

1

Page End

11

Print ISSN

1110-6999

Online ISSN

2090-2581

Article File

SCUMJ_Volume 27_Issue 8_Pages 1-11.pdf

PDF . 339.3kB

Link

https://scumj.journals.ekb.eg/article_422097.html

Detail API

http://journals.ekb.eg?_action=service&article_code=422097

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1

Type

Original Article

Type Code

938

Publication Type

Journal

Publication Title

Suez Canal University Medical Journal

Publication Link

https://scumj.journals.ekb.eg/

MainTitle

Electrolyte Imbalances Resulting from Phototherapy Use in Neonatal Hyperbilirubinemia in Suez Canal University Hospital’s Neonatal Intensive Care Unit.

Details

Type

Article

Created At

27 Apr 2025