Pain is the greatest concern of patients in critical care units (CCUs). Uncontrolled pain triggers physical and emotional stress responses, inhibits healing, increases the risk of other complications, and increases the length of CCU stay. Most critically ill patients (CIPs) experience moderate to severe pain. Aim: This study aimed to explore the nursing staff's knowledge and attitudes regarding pain management in In Oncology Hospital Khartoum State.2023. Design: An exploratory descriptive cross-sectional survey. Methods: The study was conducted between from January 2023-february 2023 among nurses in In Oncology Hospital Khartoum State, completed the nurses' knowledge and attitude Survey Regarding Pain among palliative patients. Results: The nurses had an adequate good level of knowledge and attitudes regarding pain based on the average mean score for this factor, scores were classified into Poor knowledge (≤50%), Fair knowledge (51- 75%), and (≥76%) considered Good knowledge. . There was a statistically significant correlation between socio demographic data and their knowledge and attitude. Conclusion and recommendation: Nurses explored good levels of knowledge and attitude towards pain treatment management among palliative patients. The findings also suggested that the length of time a nurse has spent working as a registered nurse is a significant factor in determining how well the nurse handles pain.