Background: Plasmapheresis is one of the most common techniques of extracorporeal blood purification, which involves removing inflammatory mediators and antibodies. Autoimmune diseases are among the many conditions for which the technique is employed. Aim: to investigate the effect of nursing guidelines on controlling adverse events of plasmapheresis among patients with autoimmune diseases. Setting: The study was accomplished at the Main University Hospital's Hemodialysis Unit, Alexandria, Egypt. Materials and Method: To carry out this study a quasi-experimental research design was utilized. A convenient sample of 60 patients with autoimmune diseases who are scheduled for undergoing plasmapheresis procedure was selected from the above mentioned setting. Tools: Biosociodemographic characteristics structured interview schedule and plasmapheresis adverse events observational checklist, were utilized for data collection. Results: highly statistically significant differences between both groups of the study were detected as regards nausea & vomiting, fatigue, joint pain & cramps, rash & itching and insertion site swelling, where p = (0.004, 0.007, <0.001, <0.001 & <0.001) respectively after application of nursing guidelines. Conclusion: the majority of patients in the study group had a statistical significant improvement in the total mean scores during the second and third observation of plasmapheresis related adverse events after applying the nursing guidelines. Recommendation: The current study should be replicated on larger probability samples.