Carbon tetrachloride (CCl₄) is a hepatotoxin; it is frequently employed to cause liver injury in animal models. Supplementing with antioxidants may therefore be beneficial in treating its hepatotoxic effects. Thus, this study's objective was to assess the impact of caffeine (CAF) as an antioxidant on hepatotoxic rats induced by CCl₄.Thirty male albino rats were divided into two main groups. The first group n=6 control negative (-) was fed a basal diet (BD), and the second group n=24 received two weekly CCl₄ (2 mg/kg bw) to cause hepatotoxicity, then separated into four subgroups. Subgroup 1 was served as a positive group (+) that received a BD only. Subgroups 2, 3, and 4 received BD and treated with an oral intake of 10, 30 and 50 mg CAF/kg/bw daily. Liver and renal function tests, lipid profile, lipid peroxidation markers, antioxidant enzymes, and histological tests were carried out at the end of treatment.  Oral daily treatments of CAF 30 and 50 mg/kg bw for 28 days exhibited a decrease in liver enzyme activities compared with control and restored serum albumin levels. On the other side, the previous two interventions caused a significant (p≤0.05) decrease in the serum lipid profile of the hepatotoxic rats (positive control group) after they were fed daily for four weeks by different rates: 16%, 23.5%, 33.8%, 41.6%, 47%, 63.9%, 33.8%, and 41.9% for total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-c), and very low-density lipoprotein cholesterol (VLDL-c), respectively. Our findings suggest that CAF might protect against oxidative stress and CCl₄-induced liver damage.