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Lipid and Essential Oil Profiles of Gliricidia sepium (Jacq.) Kunth. ex. Walp. Leaves and Flowers with Antifungal Effects Against Fluconazole-Resistant Candida albicans

Article

Last updated: 27 Apr 2025

OverviewSimilar Items

Subjects

-

Tags

Organic chemistry

Abstract

The study analyzed the chemical composition and antimicrobial activity of essential oils and lipids from Gliricidia sepium (Jacq.) Kunth. ex. Walp. leaves and flowers. Gas chromatography-mass spectrometry analysis (GC-MS) revealed high levels of unsaturated fatty acids, with arachidonic acid being the most abundant in both leaves (39.56%) and flowers (83.66%). The leaves had high hydrocarbons, including betulin (29.23%), while the flowers contained a mix of hydrocarbons and sterols/triterpenoids, with betulin (44.39%) as the main compound. The GC-MS analysis of Gliricidia sepium (Jacq.) Kunth. ex. Walp. essential oils found eucalyptol (24.09%) and d-limonene (18.05%) as the main components in the flowers, while coumarin (33.52%) and estragole (15.48%) were the chief components in the leaves. Essential oils from leaves and flowers were mostly inactive against several bacteria and fungi, but the leaves' essential oil showed antifungal activity against fluconazole-resistant Candida albicans and weak activity against Salmonella typhi. The antifungal effect of the leaves' essential oil is likely due to coumarin, estragole, and betulin

DOI

10.21608/ejchem.2024.323274.10497

Keywords

Lipid profile, Essential oils, Gliricidia sepium (Jacq.) Kunth. ex. Walp, antifungal activity, Fluconazole-resistant Candida albicans

Authors

First Name

Aya

Last Name

Wafaey

MiddleName

A.

Affiliation

Pharmacognosy Department, Faculty of Pharmacy, Cairo University, Kasr El-Aini, Cairo 11562, Egypt

Email

aya.wafaey@pharma.cu.edu.eg

City

-

Orcid

0009-0001-4871-469X

First Name

Seham

Last Name

El Hawary

MiddleName

-

Affiliation

Department of Pharmacognosy, Faculty of Pharmacy, Cairo University

Email

seham.elhawary@pharma.cu.edu.eg

City

Cairo

Orcid

0000-0002-6823-1142

First Name

shaymaa

Last Name

ismail

MiddleName

Abdalla

Affiliation

Department of Chemistry of Natural and Microbial Products, Pharmaceutical and Drug Industries Research Institute, National Research Centre, 33 El-Bohouth St., Dokki, Cairo 12622, Egypt.

Email

shaymaabdallaismail@gmail.com

City

-

Orcid

-

First Name

Sherif

Last Name

Mohamed

MiddleName

Salah

Affiliation

National Research Centre, Dokki, Cairo, Egypt

Email

shereifsalah@yahoo.com

City

Cairo

Orcid

0000-0003-2958-6802

First Name

Mohamed

Last Name

Abdelhameed

MiddleName

Fayed

Affiliation

Pharmacology department, medical division, national research centre

Email

fayed.nrc@gmail.com

City

Cairo

Orcid

0000-0001-6100-6498

First Name

farid

Last Name

kirollos

MiddleName

-

Affiliation

department of pharmacognosy, faculty of pharmacy, Cairo university

Email

farid.kirollos@pharma.cu.edu.eg

City

Giza

Orcid

-

Volume

68

Article Issue

6

Related Issue

54962

Issue Date

2025-06-01

Receive Date

2024-09-23

Publish Date

2025-06-01

Page Start

27

Page End

41

Print ISSN

0449-2285

Online ISSN

2357-0245

Article File

EJCHEM_Volume 68_Issue 6_Pages 27-41.pdf

PDF . 1.5MB

Link

https://ejchem.journals.ekb.eg/article_389778.html

Detail API

http://journals.ekb.eg?_action=service&article_code=389778

Order

389,778

Type

Original Article

Type Code

297

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

MainTitle

Lipid and Essential Oil Profiles of Gliricidia sepium (Jacq.) Kunth. ex. Walp. Leaves and Flowers with Antifungal Effects Against Fluconazole-Resistant Candida albicans

Details

Type

Article

Created At

09 Apr 2025