Background: Hepatitis C virus (HCV) is a major public health challenge globally, with Egypt bearing a disproportionate burden. Objective: This study aimed to assess HCV awareness and knowledge among Egyptian adults and identify associated factors. Patients and methods: This cross-sectional study was conducted using an online, self-administered questionnaire distributed via social media including a total of 534 respondents. The instrument, developed through literature review and expert consultation, evaluated participants' sociodemographic characteristics and knowledge of HCV features and transmission modes. Results: About half (49%) of participants demonstrated good HCV knowledge (≥75% score). While, 91.2% correctly recognized blood borne transmission, just 29.6% identified sexual transmission. Misconceptions were prevalent, with 54.8% erroneously believing that HCV is bacterial and that vaccination could prevent the infection. Multivariate regression analysis revealed that younger age (OR = 5.79, p < 0.001), higher education (OR = 8.81, p = 0.045), and participation in the screening campaign (OR = 1.69, p = 0.007) were significant predictors of better knowledge. Conclusion: Significant knowledge gaps and misconceptions about HCV persist among Egyptian adults. Enhancing public health education—particularly through digital platforms—is essential to improve awareness and support ongoing efforts to sustain HCV elimination.