Emulsions have served as common adjuvants in veterinary medicine, especially in poultry. Newcastle disease (ND) is a serious worldwide risk to the production of poultry. due to its widespread distribution and substantial economic impact. This study aimed to assess the efficacy of an intramuscularly administered vaccine containing inactivated Newcastle Disease Virus (NDV) when used with the innovative water-in-oil (W/O) emulsion adjuvants from Coral Biotechnology In this study, Two formulations of inactivated NDV vaccine were formulated; first one is LaSota, which has genotype VIId and was made using CORALVAC RZ 528 and Montanide ISA 71 as adjuvant. A 1:1 combination of the Lasota strain and genotype VIId was used. To evaluate the effectiveness of the proposed vaccines against 106 EID50/0.5 ml of the genotype VIId Newcastle disease virus Egyptian isolated strain (GenBank accession number: JX647839) challenge trials were carried out in specified pathogen-free (SPF) chicks. Every group that received vaccinations showed complete protection. In contrast to the non-vaccinated control group, the combination vaccine produced the greatest hemagglutination inhibition (HI) titers six weeks after vaccination and markedly reduced