Background: Red blood cells (RBCs) or erythrocytes are differentiated from each other based on their surface antigen structures. It was Karl Landsteiner who first discovered the ABO blood group (BG) system in 1900 and rhesus (Rh) BG later, however, the ABO and Rh BG system have fundamental importance in blood transfusions. Therefore, a suitable cross-matching test between the intended donor and the patient is highly recommended and is a part of routine clinical analysis. Methods: The data was obtained from data records of Alyameny laboratory files in Alexandria city, Egypt, the Blood groups and Rh results for 5928 patients were collected from data records in 19 years (2002- 2020), in Al-Raml district the residence of this district coming from most Egyptian governorates from Alexandria to Aswan, so this study near to be about Prevalence of ABO and Rh blood groups in Egypt with limitation in the number of participants is only 5928.
Results: This study showed that blood group A had the highest frequency (32.4%), and the frequency of O, B, and AB blood groups was 31.8%, 25.3%, and 10.5%, respectively. This study reported that the frequency of Rh-positive is higher than Rh-negative in all blood groups. In blood group A, Rh-positive is 89.8%; in blood group O, Rh-positive is 89.4%; in blood group B, Rh-positive is 89.9%; in blood group AB, Rh-positive is 91.7%. In conclusion: In this study, the prevalence of blood group A > O> B>AB.