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420337

Biochemical characterization and anticancer activity of newly isolated haloalkaliphilic bacterial strain against hepatocellular carcinoma in vitro

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Last updated: 09 Apr 2025

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Abstract

Incidence and mortality rates of liver cancer vary widely geographically, making it the sixth most common cancer in the world. Microorganisms that grow in high-salinity environments can produce bioactive compounds for therapeutic applications in the pharmaceutical field. In this study, a bacterial strain, Marinobacter HA2, was isolated from El-Hamra Lake in Wadi El-Natrun, Egypt. The biochemical features and anticancer activity were investigated. The cytotoxicity of the crude extract was assessed using the HepG2 cell line and normal human peripheral blood lymphocytes (HPBL) in vitro. The IC50 of the crude extract using the MTT test on the HepG2 cell line was calculated at 82±1.4 µg/ml.

DOI

10.21608/jmals.2020.420337

Keywords

liver cancer, haloalkaliphilic bacteria, human peripheral blood lymphocytes, Marinobacter HA2, Wadi El-Natrun, HePG2

Authors

First Name

Islam

Last Name

El-Garawani

MiddleName

M.

Affiliation

Department of Zoology, Faculty of Science, Menoufia University, Menoufia 32511, Egypt

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First Name

Sabha

Last Name

El-Sabbagh

MiddleName

M.

Affiliation

Department of Botany and Microbiology, Faculty of Science, Menoufia University, Menoufia 32511, Egypt

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City

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Orcid

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First Name

Nasser

Last Name

Abbas

MiddleName

H.

Affiliation

Department of Molecular Biology, Genetic Engineering and Biotechnology Research Institute, University of Sadat City, Sadat City 32958, Egypt

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Orcid

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First Name

Muhammad

Last Name

Zayed

MiddleName

-

Affiliation

Department of Botany and Microbiology, Faculty of Science, Menoufia University, Menoufia 32511, Egypt

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City

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Orcid

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First Name

Afaf

Last Name

Elsayed

MiddleName

-

Affiliation

Department of Botany and Microbiology, Faculty of Science, Menoufia University, Menoufia 32511, Egypt

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City

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Orcid

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First Name

Hany

Last Name

Ahmed

MiddleName

S.

Affiliation

Department of Botany and Microbiology, Faculty of Science, Menoufia University, Menoufia 32511, Egypt

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Volume

2

Article Issue

3

Related Issue

54843

Issue Date

2020-09-01

Receive Date

2020-05-01

Publish Date

2020-08-15

Page Start

39

Page End

47

Print ISSN

2636-4093

Online ISSN

2636-4107

Article File

JMALS_Volume 2_Issue 3_Pages 39-47.pdf

PDF . 475.4kB

Link

https://jmals.journals.ekb.eg/article_420337.html

Detail API

http://journals.ekb.eg?_action=service&article_code=420337

Order

420,337

Type

Original Article

Type Code

1,104

Publication Type

Journal

Publication Title

Journal of Medical and Life Science

Publication Link

https://jmals.journals.ekb.eg/

MainTitle

Biochemical characterization and anticancer activity of newly isolated haloalkaliphilic bacterial strain against hepatocellular carcinoma in vitro

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Type

Article

Created At

09 Apr 2025