The study's goal was to assess the toxicity of Oxamyl, Abamectin, fenamiphos, cadusafos, Datura stramonium AgNPs , Azadirachta indica AgNPs, Nerium oleander AgNPs, Citrullus coloroynthis AgNPs produced in an environmentally friendly manner by combining an aqueous extract of the appropriate salt (sliver nitrate) with enzymes that serve as markers of soil fertility and poulution in tomato plants (Lycopersicon esculentum). Results showed the insecticides and the nanoparticles extracts in order of decreasing Meloidogyne incognita in tomato plants were Oxamyl ˃ Abamectin ˃ fenamiphos ˃ cadusafos ˃ D. stramonium AgNPs ˃ A. indica AgNPs ˃ N. oleander AgNPs ˃ C. coloroynthis AgNPs. The activity of the enzymes was unaffected by D. stramonium AgNPs , A. indica AgNPs, N. oleander AgNPs and C. coloroynthis AgNPs applied on tomato plants. Plant extracts' nano silver particles may serve as a starting point for an effective biopesticide formulation. The concentration of available nitrogen, phosphoruse and potassium in the soil increased with the increase in the concentration of the urease, phosphatase and dehydrogenase enzymes is soil, respectivally. As a result, urease, phosphatase and dehydrogenases activity have been regarded as a more trustworthy gauge for the early assessment of quality changes brought on by soil management. also easurements of enzymatic activity can be utilised as biochemical markers of soil quality.