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Potential of Ionophores as A Feed Additive for Sustainable Beef Cattle Production: Review article

Article

Last updated: 09 Apr 2025

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Subjects

-

Tags

Animal Nutrition

Abstract

Ionophores are naturally occurring polyether antibiotics that disrupt ion balance in bacterial cells by selectively transporting metal ions across lipid membranes, primarily affecting Gram-positive bacteria in the rumen. The use of ionophores as a feed additive in sustainable beef cattle production offers a promising and innovative solution to key challenges in livestock farming, such as enhancing feed efficiency, lowering methane emissions, and promoting animal health. However, their use is surrounded by several misconceptions, which can lead to confusion among consumers, policymakers, and even within the agricultural industry. This review aims to assess the advantages, disadvantages, and safety aspects of ionophore use in beef cattle production. Published literature related to ionophores in cattle diets and their effects was collected from PubMed, ScientificGate, Google Scholar, ResearchGate and Academia. Ionophores have been reported to reduce rumen disorders like bloat and acidosis. Ionophores reduce methane emissions by altering ruminal fermentation to favor propionate production over acetate and butyrate. Ionophores may exert varying effects depending on the animal, diet, and type and dose of ionophore administered. Studies suggest limited cross-resistance to medically important antibiotics. As ionophores are metabolized and excreted rapidly, it is expected to have minimal adverse effects on human health.Overall, ionophores are promising feed additives that may play a significant role in sustainable beef cattle production, offering producers the opportunity to improve profitability while reducing environmental risks.

DOI

10.21608/javs.2025.348090.1508

Keywords

Antimicrobial resistance, Environmental hazards, Ionophores, Methane reduction, rumen fermentation

Authors

First Name

Sabrina

Last Name

Seema

MiddleName

Zaman

Affiliation

Department of Animal Science and Nutrition, Faculty of Veterinary Medicine and Animal Science, Gazipur Agricultural University, Gazipur 1706, Bangladesh

Email

sabrinazaman1@gmail.com

City

-

Orcid

0009-0009-6544-7018

First Name

Moin

Last Name

Uddin

MiddleName

-

Affiliation

Department of Animal Science and Nutrition, Faculty of Veterinary Medicine and Animal Science, Gazipur Agricultural University, Gazipur-1706, Bangladesh

Email

moin4031@stu.bsmrau.edu.bd

City

-

Orcid

0009-0007-9913-3899

First Name

Shamsun

Last Name

Tamanna

MiddleName

Nahar

Affiliation

Department of Animal Science and Nutrition, Faculty of Veterinary Medicine and Animal Science, Gazipur Agricultural University, Gazipur-1706, Bangladesh

Email

nahar.tamanna4026@gmail.com

City

-

Orcid

0009-0002-3786-450X

First Name

Khatun-A-Jannat

Last Name

Esha

MiddleName

-

Affiliation

Department of Animal Science and Nutrition, Faculty of Veterinary Medicine and Animal Science, Gazipur Agricultural University, Gazipur-1706, Bangladesh

Email

jannat4021@stu.bsmrau.edu.bd

City

-

Orcid

0009-0002-5438-4604

First Name

Kazi Md.

Last Name

Al-Noman

MiddleName

-

Affiliation

Department of Dairy and Poultry Science, Faculty of Veterinary Medicine and Animal Science, Gazipur Agricultural University, Gazipur-1706, Bangladesh

Email

noman4136@stu.bsmrau.edu.bd

City

-

Orcid

0000-0002-2001-6232

First Name

S. A. Masudul

Last Name

Hoque

MiddleName

-

Affiliation

Department of Animal Breeding and Genetics, Faculty of Veterinary Medicine and Animal Science, Gazipur Agricultural University, Gazipur-1706, Bangladesh

Email

mhoqueabg@bsmrau.edu.bd

City

-

Orcid

-

First Name

Abu Sadeque Md.

Last Name

Selim

MiddleName

-

Affiliation

Department of Animal Science and Nutrition, Faculty of Veterinary Medicine and Animal Science, Gazipur Agricultural University, Gazipur-1706, Bangladesh

Email

asmselim@bsmrau.edu.bd

City

-

Orcid

0000-0001-8457-4631

First Name

Md. Morshedur

Last Name

Rahman

MiddleName

-

Affiliation

Department of Dairy and Poultry Science, Faculty of Veterinary Medicine and Animal Science, Gazipur Agricultural University, Gazipur-1706, Bangladesh

Email

morshed@bsmrau.edu.bd

City

-

Orcid

0000-0002-6474-8902

Volume

10

Article Issue

2

Related Issue

54805

Issue Date

2025-04-01

Receive Date

2025-01-06

Publish Date

2025-04-01

Page Start

35

Page End

46

Print ISSN

1687-4072

Online ISSN

2090-3308

Article File

JAVS_Volume 10_Issue 2_Pages 35-46.pdf

PDF . 544.3kB

Link

https://javs.journals.ekb.eg/article_417911.html

Detail API

http://journals.ekb.eg?_action=service&article_code=417911

Order

6

Type

Review Article

Type Code

1,129

Publication Type

Journal

Publication Title

Journal of Applied Veterinary Sciences

Publication Link

https://javs.journals.ekb.eg/

MainTitle

Potential of Ionophores as A Feed Additive for Sustainable Beef Cattle Production: Review article

Details

Type

Article

Created At

09 Apr 2025