Background: Nursing is a noble profession characterized by numerous sources of stress, leading to diminished quality of work life in addition to manifesting of negative and cynical attitudes appear that adversely affect job performance Aim: This study aimed to examine the nurses' perception towards organizational cynicism and its relation to their work life's quality in Port-Said hospitals. Design: Using of descriptive correlational design was carried out. Settings: A three hospital affiliated to Egypt health care authority were the places in which the study was conducted, namely; As-Sallam, El-Zohour, El-Nasr hospital. Subjects: Includes 247 nurses. Tools: Two tools utilized for data collection; questionnaire of organizational cynicism in addition to work life's quality. Results: It was demonstrated by the current study that 72.5% of the studied nurses had moderate perception level of organizational cynicism, meanwhile half of participants (50.2%) demonstrated moderate level of work life's quality. Conclusion: result of the study exhibited high negative statistically significant correlation between total quality of work life and organizational cynicism. Recommendations: Conduct an educational program for managers on the benefits of maintaining healthy work environment and teach nursing how to deal with work pressures to avoid cynicism