Background: Soft skills are one of the contemporary concepts that pay attention to and play a critical role in nursing. It's one of the skills that must be reserved by everyone, mainly for nurse interns. Also, nurse interns need to consistently improve their professional level by acquiring soft skills like effective communication and how to provide professional nursing care in the workplace.Aim: This study aimed to; explore the relationship between soft skills, and professionalism among nurse interns. Subjects and Method: A descriptive correlational research design was used to conduct this study on all nurse interns of the academic year (2023-2024) at the Faculty of Nursing, Port-Said University. The study subjects comprised 114 nurse interns. Two data collection tools were used; the Soft Skills Assessment Questionnaire (SSAQ) and the Nurse Interns Professionalism Assessment Scale (NIPAS). Results: The present study revealed that less than half of nurse interns reported that they had a moderate level of soft skills (42.1%) and less than half of them had a moderate level of professionalism (44.7%). Conclusion: It was evidenced that there was a highly statistically significant positive correlation between nurse interns' soft skills and their professionalism. Recommendations: The main recommendations suggested, designing and applying a training program on soft skills as critical skills for academic students is essential, and Integrating soft skills concept into undergrad and postgrad nursing curricula.