Background: Workaholism is a psychological condition characterized by excessive and compulsive engagement in work activities, driven by the need to meet organizational standards. Well-being encompasses the holistic health and quality of life of individuals. Aim: The study aimed to examine the relationship between workaholism and well-being among nurses. Design: A descriptive correlational research design was employed. Setting: The study was conducted at As Salam Hospital, El-Zohor Hospital, and Al-Hayah Hospital, all affiliated with the Health Insurance System of the Ministry of Health in Port Said Governorate. Subjects: The study involved 380 nurses. Tools: The Workaholism Questionnaire and the Nurses' Well-Being Scale were used. Results: The study found that a significant proportion of nurses (74.2%) exhibited moderate workaholism, while a similar proportion (77.9%) reported moderate well-being. Conversely, a small percentage of nurses reported low levels of workaholism (10.8%) and well-being (2.1%). Conclusion: The correlation coefficient (r = -0.033, p = 0.524) indicated a non-significant negative correlation between workaholism and well-being. Recommendation: Based on these findings, it is recommended that healthcare organizations implement strategies to promote work-life balance, provide support interventions, and regularly assess nurses' well-being to mitigate the effects of workaholism.