Background: The problem of substance use is becoming one of the most serious and rapidly growing phenomena all over the world. Self-empowerment and treatment motivation are tools that can be used to take control over life after addiction. Aim: this study aimed to explore the relationship between self- empowerment, treatment motivation and relapse among substance abusers in Port Said city. Subjects and Method: Design: A descriptive correlation research design was utilized. Setting: the study conducted in psychiatric outpatient clinic through hotline for substance abuse at Port Said Psychiatric Health and Addiction Treatment Hospital, Egypt. Subjects: a purposive sample of 186 substance abusers were included. Tools: three tools used for data collection consisted of; the Self-empowerment Scale, Treatment Motivation Questionnaire, and addiction Relapse Scale. The Results: The current findings showed that, the highest percentages of the studied patients had moderate sense of self-empowerment, the majority of the studied patients had very true treatment motivation, and less than half of them had moderate level of relapse. Conclusion: There was statistically significant positive correlation between studied patients' level of Self-empowerment and motivational treatment. While, there was statistically significant negative correlation between studied patients' self-empowerment and addiction relapses and between addiction relapses and motivational treatment. Recommendations: Designing and implementing continuous counseling programs based on patients' experiences and needs to advice knowledge regarding substance abuse issues to increase self-empowerment and improve their treatment motivation to prevent relapse of drug addiction.