Abstract:
Airway inflammation and imbalance between oxidant/anti-oxidant mechanisms are postulated to play a major role in the pathogenesis of COPD.
The work aimed to evaluate serum uric acid among COPD patients and its correlation with the severity of the disease.
Patients and methods: A retrospective cross-sectional study included 50 COPD patients, who attended Benha University Hospital from March 2022 to November 2023. All patients were subjected to the following; written consent from the patient, full history and clinical examination, ABG, CXR (P-A), pulmonary function tests, measuring serum creatinine and urea, measuring serum uric acid by enzymatic colorimetric assay in a fully automated analyzer.
Results: There was a highly significant negative correlation between patients' serum uric acid levels and FEV1.There was a highly significant negative correlation between patients' serum uric acid levels and FEV1̸ FVC
Conclusion: uric acid could be used as a chemical biomarker in predicting COPD severity and staging.
Keywords: COPD, uric acid, severity