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398973

Diagnostic Value of Presepsin for Bacterial Infection in Patients with Liver Cirrhosis

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Last updated: 09 Apr 2025

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Abstract

Background: Presepsin serum levels can be measured to assess the severity of an infection and to track the clinical effects of therapy interventions. The aim of this work is to evaluate the diagnostic capacity of presepsin serum levels in the early detection of bacterial infections in cirrhotic patients and its usefulness in evaluating response to antibiotic therapy.
Methods: This prospective case control study included 52 patients with decompensated liver cirrhosis of various etiologies, with an age of 18 or older and both sexes . Patients were divided into two equal groups: Group A: decompensated cirrhotic patients without bacterial infection and group B: decompensated cirrhotic patients with bacterial infection. Presepsin levels were analyzed by receiving operating characteristic curve to evaluate their ability to predict bacterial infection.
Results: Albumin levels were significantly lower in group B than group A (P=0.022). C-reactive protein and Presepsin levels were significantly higher in group B than group A (P

DOI

10.21608/bmfj.2024.333991.2246

Keywords

Diagnosis, presepsin, bacterial infection, Liver cirrhosis

Authors

First Name

Yehia

Last Name

Younes

MiddleName

Sadek

Affiliation

Professor of Hepatology, Gastroenterology, and Infectious Diseases Faculty of Medicine - Benha University

Email

dr.yehiasadek56@gmail.com

City

-

Orcid

-

First Name

Hatem Samir

Last Name

Abdel-Raouf Elegily

MiddleName

-

Affiliation

Professor of Hepatology, Gastroenterology, and Infectious Diseases Faculty of Medicine - Benha University

Email

hatem.abdel-raouf@fmed.bu.edu.eg

City

-

Orcid

-

First Name

Marwa

Last Name

Ateya

MiddleName

Abdel Monem

Affiliation

Assistant professor of Clinical Pathology Faculty of Medicine - Zagazig University

Email

marwaamonem@hotmail.com

City

-

Orcid

-

First Name

Hassan

Last Name

El sayed

MiddleName

-

Affiliation

Assistant professor of Microbial Biotechnology Department, Biotechnology Research Institute, National Research Centre, Egypt

Email

hassanaboelnor@yahoo.com

City

-

Orcid

-

First Name

Ahmed

Last Name

Yousif

MiddleName

Abdo

Affiliation

Lecturer of Gastroenterology and Infectious Diseases Department, Ahmed Maher Teaching Hospital, Ministry of Health, Cairo, Egypt

Email

ahmedabdo50504@gmail.com

City

-

Orcid

-

First Name

Mohammed

Last Name

Soliman

MiddleName

Salman

Affiliation

M.B.B. Ch

Email

msa854182@gmail.com

City

-

Orcid

-

Volume

42

Article Issue

4

Related Issue

54800

Issue Date

2025-04-01

Receive Date

2024-11-05

Publish Date

2025-04-01

Page Start

509

Page End

515

Print ISSN

1110-208X

Online ISSN

2357-0016

Article File

BMFJ_Volume 42_Issue 4_Pages 509-515.pdf

PDF . 405.6kB

Link

https://bmfj.journals.ekb.eg/article_398973.html

Detail API

http://journals.ekb.eg?_action=service&article_code=398973

Order

15

Type

Original Article

Type Code

787

Publication Type

Journal

Publication Title

Benha Medical Journal

Publication Link

https://bmfj.journals.ekb.eg/

MainTitle

Diagnostic Value of Presepsin for Bacterial Infection in Patients with Liver Cirrhosis

Details

Type

Article

Created At

09 Apr 2025