Inflammatory bowel diseases (IBDs) are groups of chronic inflammatory disorders had continuous recurrent swelling and irritation of the inner lining of the intestines. NPs increase solubility and bioavailability of drugs. Curcumin is recognized by its wound-healing properties and has antimicrobial, antioxidant, and anti-inflammatory effects. Aim of the work: our study aimed to evaluate efficacy of combination of silver nanoparticles with curcumin in the management of inflammatory bowel disease" through rectal route". Patients and Methods: the study was done from October 2023 to June 2024, included ninety participates with ulcerative colitis. Treatment Group: 45 patients received a combination of silver-nanoparticles and curcumin via enema, and injection into the rectal ulcer and mucosa, along with oral mesalazine. Control Group: 45 patients received a placebo enema with oral mesalazine. Disease severity was evaluated by clinical activity and endoscopic indices, at the start, every 2 months, and at the end of the 6-month trial. Results: Symptoms of Bowel frequency, Urgency of defecation, Blood in stool and General well-being of patients were improved in group treated with curcumin. Extracolonic features of inflammatory bowel disease has been controlled. There was improvement in both clinical response and clinical remission when they were compared to patients treated with ordinary drugs. Evaluation by colonoscope for vascular pattern and erosions/ulcers showed wonderful healing rate in curcumin group, and showed stoppage of bleeding due to healing of mucosa.Conclusion: Using of Curcumin combined with Silver-Nano particles through rectal route can be effective (IBDs) treatment option and improve patients' quality of life