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394167

Role of MicroRNA (182) in Differentiation Between Benign and Malignant Pleural Effusion

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Last updated: 09 Apr 2025

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Abstract

Background: Differential diagnosis between malignant pleural effusion (MPE) and benign pleural effusion (BPE) remains a clinical challenge. Aim: to evaluate the role of microRNA (182) in differentiation between tuberculous (TPE) and malignant pleural effusion (MPE). Methods: This cross-sectional study included 60 patients admitted at the Chest Department, Benha University Hospital. Patients were divided into two groups based on pathology results: Group A (n=45): MPE and Group B: (n=15): TPE. miRNA 182 was measured by qt PCR in both groups and expressed as ΔΔCT and fold change(2-ΔΔCt ) Results: No statistically significant difference between MPE and TPE regarding ΔΔCT and fold change and the level did not differ significantly between malignant types. Adenosine deaminase (ADA) can significantly differentiate between malignant and TB groups (P

DOI

10.21608/bmfj.2024.331386.2240

Keywords

MicroRNA(182), differentiation, benign, Malignant pleural effusion

Authors

First Name

Amira

Last Name

Allam

MiddleName

Hussein

Affiliation

Chest Department, Faculty of Medicine, Benha University

Email

amrhoc@yahoo.com

City

BENHA

Orcid

0000-0003-3976-9899

First Name

Magdy

Last Name

Omar

MiddleName

Mohamed

Affiliation

Pofessor of Chest Diseases, Faculty of Medicine, Benha University

Email

mag2dy@gmail.com

City

Benha

Orcid

-

First Name

Hmasat

Last Name

El Noury

MiddleName

Abd El Hafez

Affiliation

Assistant Professor of Clinical Pathology, Faculty of Medicine - Benha University

Email

ahamasata9@gmail.com

City

Benha

Orcid

-

First Name

Abeer

Last Name

Rawy

MiddleName

Mohamed

Affiliation

Assistant Professor of Chest Diseases, Faculty of Medicine, Benha University

Email

abeermohamed@gmail.com

City

Benha

Orcid

-

First Name

Toqa

Last Name

Anwar

MiddleName

Ayman

Affiliation

M.B.B.Ch, Faculty of Medicine, Benha University

Email

loaiayman.loaiayman@gmail.com

City

benha

Orcid

-

First Name

Rehab

Last Name

El Sawy

MiddleName

El Sayed

Affiliation

Assistant Professor of Chest Diseases, Faculty of Medicine, Benha University

Email

rehab132@gmail.com

City

Benha

Orcid

-

Volume

42

Article Issue

4

Related Issue

54800

Issue Date

2025-04-01

Receive Date

2024-10-26

Publish Date

2025-04-01

Page Start

403

Page End

418

Print ISSN

1110-208X

Online ISSN

2357-0016

Article File

BMFJ_Volume 42_Issue 4_Pages 403-418.pdf

PDF . 1.1MB

Link

https://bmfj.journals.ekb.eg/article_394167.html

Detail API

http://journals.ekb.eg?_action=service&article_code=394167

Order

7

Type

Original Article

Type Code

787

Publication Type

Journal

Publication Title

Benha Medical Journal

Publication Link

https://bmfj.journals.ekb.eg/

MainTitle

Role of MicroRNA (182) in Differentiation Between Benign and Malignant Pleural Effusion

Details

Type

Article

Created At

09 Apr 2025