ManageChatDiscover
419226

Forty and Beyond: A SWOT Analysis of PGT-A in the Context of Aging and Fertility

Article

Last updated: 09 Apr 2025

OverviewSimilar Items

Subjects

-

Tags

Assisted reproduction

Abstract

Preimplantation genetic testing for aneuploidy (PGT-A) is widely used in in vitro fertilization (IVF) to detect chromosomal abnormalities in embryos. This testing employs various platforms—including quantitative PCR, array comparative genomic hybridization (aCGH), and next-generation sequencing (NGS)—each with its own advantages and limitations. The goal of these technologies is to enhance clinical outcomes, reduce the time to pregnancy, and ultimately improve the likelihood of delivering a healthy baby. Additionally, emerging approaches such as non-invasive PGT using spent culture medium show promise for future application.
However, it is important to recognize that PGT-A functions as a screening tool rather than a definitive indicator of the chromosomal status of embryos or fetuses. While advocates claim that PGT-A enhances IVF outcomes, critics argue that it lacks adequate clinical validation and may reduce live birth rates due to its high false-positive rate.This article employs a SWOT analysis to evaluate the advantages, challenges, opportunities, and risks of PGT-A in women of advanced maternal age.

DOI

10.21608/jrme.2025.362026.1029

Keywords

PGT-A, swot, Strength, Weakness, opportunity

Authors

First Name

Hassan

Last Name

Maghraby

MiddleName

-

Affiliation

Obstetrics and Gynecology Department, Faculty of Medicine, Alexandria University, Egypt., Egyptian Foundation of Reproductive Medicine and Embryology (EFRE), Egypt.

Email

hassanmaghraby@gmail.com

City

-

Orcid

0000-0003-3661-1594

First Name

Hisham

Last Name

Ali Saleh

MiddleName

-

Affiliation

Obstetrics and Gynecology Department, Faculty of Medicine, Alexandria University, Egypt., Egyptian Foundation of Reproductive Medicine and Embryology (EFRE), Egypt., Agial Fertility Center, Alexandria, Egypt.

Email

hishamalisaleh@gmail.com

City

Alexandria

Orcid

-

First Name

Ashraf

Last Name

Abo Ali

MiddleName

-

Affiliation

Egyptian Foundation of Reproductive Medicine and Embryology (EFRE), Egypt., Madina Fertility Center, Madina Women's Hospital, Alexandria, Egypt.

Email

aboalimadinahospital@gmail.com

City

Alexandria

Orcid

-

First Name

Hayat

Last Name

Sharaf

MiddleName

-

Affiliation

Obstetrics and Gynecology Department, Faculty of Medicine, Alexandria University, Egypt., Egyptian Foundation of Reproductive Medicine and Embryology (EFRE), Egypt., Obstetrics and Gynecology Department, Faculty of Medicine, Hodeidah University, Al-Hodeidah, Yemen.

Email

hayatsharaf999@yahoo.com

City

-

Orcid

-

First Name

Amr

Last Name

Shehata

MiddleName

-

Affiliation

Egyptian Foundation of Reproductive Medicine and Embryology (EFRE), Egypt., Obstetrics and Gynecology Department, Faculty of Medicine, Aswan University, Egypt.

Email

amr.shehata@med.aswu.edu.eg

City

Alexandria

Orcid

-

First Name

Mohamed

Last Name

Elmahdy

MiddleName

-

Affiliation

Obstetrics and Gynecology Department, Faculty of Medicine, Alexandria University, Egypt. , Egyptian Foundation of Reproductive Medicine and Embryology (EFRE), Egypt.

Email

mahdy_moh@yahoo.com

City

-

Orcid

0000-0003-4332-9845

First Name

Nehal

Last Name

Adel

MiddleName

-

Affiliation

Egyptian Foundation of Reproductive Medicine and Embryology (EFRE), Egypt., Madina Fertility Center, Madina Women's Hospital, Alexandria, Egypt.

Email

nehal_adel83@hotmail.com

City

Alexandria

Orcid

0000-0002-2853-8334

First Name

Heba

Last Name

Hassan

MiddleName

-

Affiliation

Dar Alteb Infertility Center, Alexandria, Egypt., Egyptian Foundation of Reproductive Medicine and Embryology (EFRE), Egypt.

Email

hebahali85@gmail.com

City

Alexandria

Orcid

-

First Name

Sherif

Last Name

Gaafar

MiddleName

-

Affiliation

Obstetrics and Gynecology Department, Faculty of Medicine, Alexandria University, Egypt., Egyptian Foundation of Reproductive Medicine and Embryology (EFRE), Egypt., Madina Fertility Center, Madina Women's Hospital, Alexandria, Egypt.

Email

shgaafar301@yahoo.com

City

-

Orcid

-

Volume

1

Article Issue

4

Related Issue

54794

Issue Date

2025-02-01

Receive Date

2025-02-19

Publish Date

2025-02-01

Page Start

262

Page End

275

Online ISSN

3009-7282

Article File

JRME_Volume 1_Issue 4_Pages 262-275.pdf

PDF . 424.7kB

Link

https://jrme.journals.ekb.eg/article_419226.html

Detail API

http://journals.ekb.eg?_action=service&article_code=419226

Order

9

Type

Original Article

Type Code

2,940

Publication Type

Journal

Publication Title

Journal of Reproductive Medicine and Embryology

Publication Link

https://jrme.journals.ekb.eg/

MainTitle

Forty and Beyond: A SWOT Analysis of PGT-A in the Context of Aging and Fertility

Details

Type

Article

Created At

09 Apr 2025