ABSTRACT

Backround: A delay in childbearing to later n life has increase the number of women of ‎advance maternal age (AMA) opting for assisted reproductive, women should be made ‎aware that age-related changes to fertility including decline in Oocyte reserve and quality in ‎addition to increase in the number of Oocyte chromosomal aberration.‎

Aim: To evaluate the effect of maternal age on the outcomes of in vitro fertilization (IVF) ‎and embryo transfer (ET) in fresh and frozen embryo cycles.‎

Method: This is a retrospective observational cohort study from a last 1000 patients aged ‎‎40-48 years in sequence without exclusion, who underwent IVF with intra-cytoplasmic ‎sperm injection in Al Amal IVF Center – Misrata.‎
The study assess the embryo transfer rate, clinical pregnancy and miscarriage rates.‎

Results: The study includes last 1000 cases aged above 40 years old underwent ICSI/IMSI ‎cycle. In fresh embryo cycle 500 cases and in frozen embryo cycle 500 cases, four groups of ‎different maternal age periods were compared, (40-42) years old group, (42-44) years old ‎group, (44-46) years old group and (46-48) years old group. The retrieved Oocyte number ‎and clinical pregnancy rate were significantly lower in groups of higher maternal age, while ‎the miscarriage rate was significantly higher in groups of good quality embryo.‎

Conclusion: Patient with higher maternal age had low IVF outcomes and patients over 40 ‎years old have poor IVF outcome and high miscarriage rate, clinicians should be very ‎cautious in counseling of this age group and give the expected incidence.‎