Objectives: The current study aimed to assess the effect of arthrocentesis followed by
injection of platelet rich plasma (PRP) versus arthrocentesis in the management of anterior
disc displacement with reduction (DDWR) disorder. Materials and methods: Seventy-four
patients ( mean age 29.3 years) with anterior DDWR were randomized and divided according
to a predetermined eligiblity criteria into two equal groups: arthrocentesis (control) and
arthrocentesis with PRP injection ( study).For both groups, Pain intensity was assessed using
visual analogue scale and maximum mouth opening (MMO) preoperatively, immediate, 1
week, 1 month, 3 and 6 months postoperatively. Moreover, the disc displacement angle was
recorded preoperative and after 6 months. Results: Pain was significantly reduced in the
study group compared to the control group only at 1 week, 1 month, 3 and 6 months (p <
0.05). However, there was non significant difference among groups regarding MMO at all time
intervals or disc position angle after 6 months (p>0.05). Conclusions: PRP resulted in pain
reduction for most of the period of follow up, with no apparent positive effect on MMO or disc
position. Clinical Relevance: The study evaluates whether the anti-inflammatory and growth
stimulation effect of PRP is reflected on reduction of pain intensity and disc position in the
management of patients suffering from DDWR. Clinical trial registration NCT05983653