Introduction: Aim of the current study was to reveal the effect of centric relation(CR)/maximum intercuspation (MI) discrepancy on changing the posterior crossbite diagnosis in adult orthodontic patients. Material and method: One hundred and one patients were recruited in the current study. For each patient both MI and CR were recorded using digital workflow. The presence or absence of unilateral and bilateral posterior crossbite was identified in each occlusion. Results:Mandibular displacement from CR to MI affected the clinical presentation of posterior crossbite.There was a statistically significant difference between incidence of bilateral posterior crossbite in centric relation records versus maximum intercuspation with less significant difference in the incidence of unilateral posterior cross bite while evaluating the 2 occlusion patterns. Conclusion: Based on the reached results, there is increased incidence of posterior cross bite development in centric occlusion in comparison to the maximum intercuspation. Recording the centric occlusion in orthodontic patients might be of diagnostic value regarding the development of posterior cross bite.