Background: Find out how NF-κβ/p65 plays a role in breast cancer development. NF-κβ/p65 expression was investigated in breast cancer and its molecular subgroups to ascertain the association between NF-κβ/p65 expression and clinicopathological features. This study aimed to assess the immunohistochemistry expression of NF-κβ/p65 in invasive breast cancer was the goal of the current investigation. Both clinicopathological characteristics and immunohistochemical-based subtypes of the patients under study were evaluated in relation to the expression of NF-κβ/p65. Methods: The immunohistochemistry expression of the NF-κβ/p65 receptor was examined in 82 paraffin-embedded slices from invasive breast cancer. Results: NF-κβ/p65 expression was found to be substantially linked with tumor size, grade, pathological stage, Her2-enriched and triple negative subtypes, and Ki67 levels. Furthermore, there was a significant inverse association between the expression of NF-κβ/p65 and the progesterone receptor (PR) and oestrogen receptor (ER). There was no significant correlation between age, axillary lymph node status, distant metastases, or tumor histological subtypes and NF-κβ/p65 expression. Conclusion: Breast cancer's aggressive biological properties have been connected to the expression of NF-κβ/p65.