Background: Work alienation and counterproductive work behavior (CWB) are two significant factors that can negatively impact organizational commitment. Alienated employees are less likely to have emotional attachment to their organization, feel obligated to stay with the organization. CWB can damage trust between employees and the organization, lower job satisfaction, and become less committed to the organization. Aim: Explore the association among work alienation, counterproductive work place behavior, and organizational commitment as perceived by nurses. Study design: Descriptive correlational research design was used. Setting: The study was conducted at Sohag University Hospital. Sample: The sample size was (266) nurses. Tools: four tools were used namely, Personal and occupational data sheet, Work alienation scale, Counterproductive workplace behavior checklist, and organizational commitment questionnaire. Results: Majority of studied nurses (94.7%) had high work alienation level, half of them (50%) had high counterproductive workplace behavior level, more than half of them (52.6%) had low organizational commitment level. Conclusion: There was high statistically significant negative correlation between organizational commitment with work alienation, and counterproductive workplace behavior. Recommendations: Give nurses recognitions on their good practice to feel proud of their selves and become more committed to the organization.