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420106

Marine algae Cystoseira indica extracted alginate alleviates toxicity and inflammation pathways in Osteoarthritis induced rat model

Article

Last updated: 09 Apr 2025

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Subjects

-

Tags

Biochemistry

Abstract

Background: Brown algae are known for synthesizing bioac-tive compounds with anti-inflammatory properties, which have shown potential in addressing inflammation-related disorders. Osteoarthritis (OA), a joint disease characterized by significant inflammation, negatively impacts overall health and quality of life. Aim:

This study aimed to evaluate the therapeutic potential of algi-nate extracted from the brown algae Cystoseira indica in miti-gating OA using a rat model. Materials & Methods: OA was induced in rats through intra-articular administration of mono-sodium iodoacetate (MIA). The experimental design included a control group, an MIA-induced OA group, and an alginate-treated group (MIA + alginate). Samples were collected at in-tervals of 2, 4, 6, and 10 weeks to assess pro-inflammatory cy-tokine levels, biochemical markers, and histopathological changes in knee cartilage. Results

OA induction led to a significant increase in pro-inflammatory and oxidative stress markers, including malondialdehyde (MDA), interleukin 1-beta (IL1β), tumor necrosis factor-alpha (TNF-α), beta-glucuronidase (β-G), acid phosphatase (ACP), and aggrecanase 1, alongside a marked reduction in glutathi-one (GSH) levels. Alginate treatment significantly mitigated OA progression, as evidenced by reduced levels of MDA, IL1β, TNF-α, β-G, ADAMTS4, and matrix metalloproteinase-3 (MMP-3), coupled with increased GSH levels and improved cartilage recovery and regeneration. Conclusion

Alginate from C. indica demonstrates significant potential in mitigating OA through its anti-inflammatory effects, highlight-ing its promise as a therapeutic agent for inflammation-related joint disorders.

DOI

10.21608/jcbr.2025.353492.1382

Keywords

Alginate, antioxidant, Anti-inflammatory, osteoarthritis, and proinflammatory cytokines

Authors

First Name

Mohamed

Last Name

Helal

MiddleName

-

Affiliation

National Institute of Oceanography and Fisheries (NIOF), Cairo, Egypt Department of Biology, University of Southern Denmark, Odense, 5230, Denmark

Email

m.helalf@gmail.com

City

Alexandria

Orcid

-

First Name

Amany

Last Name

El-Sekaily

MiddleName

-

Affiliation

National Institute of Oceanography and Fisheries (NIOF), Cairo, Egypt

Email

dramany_mas@yahoo.com

City

Alexandria

Orcid

-

First Name

Mohamed

Last Name

Shetewy

MiddleName

-

Affiliation

Applied Medical Chemistry, Medical Research Institute, Alexandria University, Alexandria, Egypt

Email

msawad2@yahoo.com

City

Alexandria

Orcid

-

First Name

Hoda

Last Name

Soliman

MiddleName

-

Affiliation

Applied Medical Chemistry, Medical Research Institute, Alexandria University, Alexandria, Egypt

Email

hodasoliman20@yahoo.com

City

Alexandria

Orcid

-

First Name

Abdallah

Last Name

Elnemr

MiddleName

-

Affiliation

Faculty of Medicine, Alexandria University, Alexandria 21526, Egypt

Email

elnemrabdallah@gmail.com

City

Alexandria

Orcid

-

First Name

Hossam

Last Name

Ghonim

MiddleName

-

Affiliation

Department of Immunology, Medical Research Institute, Alexandria University, Alexandria, Egypt

Email

ghoneim.hossam@yahoo.com

City

Alexandria

Orcid

-

First Name

Amal

Last Name

El-Sedfy

MiddleName

-

Affiliation

Department of Pathology, Medical Research Institute, Alexandria University, Alexandria, Egypt

Email

amal.mahmoud@alexu.edu.eg

City

Alexandria

Orcid

-

First Name

Aziza

Last Name

Saad

MiddleName

-

Affiliation

Applied Medical Chemistry, Medical Research Institute, Alexandria University, Alexandria, Egypt

Email

aziza.a.saad@gmail.com

City

-

Orcid

-

First Name

Jihan

Last Name

Hassan

MiddleName

-

Affiliation

Applied Medical Chemistry, Medical Research Institute, Alexandria University, Alexandria, Egypt

Email

jihanhassan222@gmail.com

City

Alexandria

Orcid

-

Volume

9

Article Issue

1

Related Issue

54011

Issue Date

2025-03-01

Receive Date

2025-01-16

Publish Date

2025-03-01

Page Start

61

Page End

70

Print ISSN

3009-6391

Online ISSN

3009-7312

Article File

JCBR_Volume 9_Issue 1_Pages 61-70.pdf

PDF . 1.0MB

Link

https://jcbr.journals.ekb.eg/article_420106.html

Detail API

http://journals.ekb.eg?_action=service&article_code=420106

Order

420,106

Type

Original Article

Type Code

885

Publication Type

Journal

Publication Title

Egyptian Journal of Cancer and Biomedical Research

Publication Link

https://jcbr.journals.ekb.eg/

MainTitle

Marine algae Cystoseira indica extracted alginate alleviates toxicity and inflammation pathways in Osteoarthritis induced rat model

Details

Type

Article

Created At

09 Apr 2025