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420105

Omitting Radiation in young adult females with Hodgkin’s Disease, Is there an Impact on Outcome?

Article

Last updated: 09 Apr 2025

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-

Tags

Inflammatory and cancer

Abstract

Background: Ionizing radiation is a breast cancer risk factor. This retrospective study aims to compare the outcome of young adolescent females diagnosed and treated with classic Hodgkin lymphoma who received chemotherapy while omitting radiotherapy for fear of the increased risk of breast cancer and those who received chemotherapy followed by radiotherapy in an attempt to explore the impact of radiotherapy on the outcome and to record the late side effects of radiotherapy as well as the incidence of breast cancer among these patients.

About 166 young adolescent females between 12 and 18 years old were diagnosed and treated with classic Hodgkin lymphoma in the Children's Cancer Hospital Egypt from July 2007 till the end of 2018, the no radiotherapy (RT) group (72 patients) received chemotherapy while omitting radiotherapy, the RT group (94 patients) received chemotherapy and radiotherapy, with 5years OS 93%, 87% respectively, and with 5years EFS 74%, 85% respectively, with P-value 0.062. The initial stage and response to treatment using interim PET CT scans post-second cycle chemotherapy were documented. The outcomes were nearly identical in the no RT and RT groups. In conclusion, omitting radiation therapy did not affect the 5-year EFS; nevertheless, the existence of positive B symptoms, an advanced stage initially, or a poor response to treatment all impacted the 5-year EFS.

DOI

10.21608/jcbr.2025.360082.1385

Keywords

Hodgkin Lymphoma, Radiotherapy, breast cancer, advanced stage, interim PET CT

Authors

First Name

Samah

Last Name

Semary

MiddleName

FA

Affiliation

Department of oncology, Beni-Suef University, Beni-Suef, Egypt. Depaetment of pediatric oncology, Children Cancer Hospital Egypt

Email

samahsemary@yahoo.com

City

-

Orcid

0000-0002-5394-3307

First Name

Emad

Last Name

Moussa

MiddleName

Ali Helmy

Affiliation

Department of Pediatric Oncology, Children Cancer Hospital Egypt, Cairo, Egypt Department of Clinical Oncology, Menufiya University, Shebeen, Egypt

Email

emad.moussa@57357.org

City

Cairo

Orcid

-

First Name

Asmaa

Last Name

Hamoda

MiddleName

-

Affiliation

Department of Pediatric Oncology, Children Cancer Hospital Egypt, Cairo, Egypt Department of Pediatric Oncology, National Cancer Institute/ Cairo University, Cairo, Egypt

Email

asmaahamoda82@hotmail.com

City

-

Orcid

-

First Name

Eman

Last Name

Nagib

MiddleName

-

Affiliation

Department of Pathology/ National Cancer Institute/ Cairo University, Cairo, Egypt Department of Pathology, Children Cancer Hospital Egypt, Cairo, Egypt

Email

eman.nagib@57357.org

City

-

Orcid

-

First Name

Salma

Last Name

Abdelaziz

MiddleName

-

Affiliation

Department of Nuclear Medicine, Children Cancer Hospital Egypt, Cairo, Egypt Department of Nuclear Medicine, National Cancer Institute/ Cairo University, Cairo, Egypt

Email

salma.abdelaziz@57357.org

City

-

Orcid

-

First Name

Mahmoud

Last Name

Hamza

MiddleName

-

Affiliation

Department of Clinical Research, Children Cancer Hospital Egypt, Cairo, Egypt

Email

mahmoud.hamza@57357.org

City

-

Orcid

-

First Name

Madeha

Last Name

Elwakil

MiddleName

-

Affiliation

Department of radiodiagnosis/ National Cancer Institute/ Cairo University, Cairo, Egypt Department of Radiodiagnosis, Children Cancer Hospital Egypt, Cairo, Egypt

Email

madeha.elwakil@57357.org

City

-

Orcid

-

First Name

Mohamed

Last Name

Zaghloul

MiddleName

-

Affiliation

Department of Radiotherapy, National Cancer Institute/ Cairo University, Cairo, Egypt Department of Radiotherapy, Children Cancer Hospital Egypt, Cairo, Egypt

Email

mszagh@yahoo.com

City

-

Orcid

-

Volume

9

Article Issue

1

Related Issue

54011

Issue Date

2025-03-01

Receive Date

2025-02-12

Publish Date

2025-03-01

Page Start

51

Page End

60

Print ISSN

3009-6391

Online ISSN

3009-7312

Article File

JCBR_Volume 9_Issue 1_Pages 51-60.pdf

PDF . 859.4kB

Link

https://jcbr.journals.ekb.eg/article_420105.html

Detail API

http://journals.ekb.eg?_action=service&article_code=420105

Order

420,105

Type

Original Article

Type Code

885

Publication Type

Journal

Publication Title

Egyptian Journal of Cancer and Biomedical Research

Publication Link

https://jcbr.journals.ekb.eg/

MainTitle

Omitting Radiation in young adult females with Hodgkin’s Disease, Is there an Impact on Outcome?

Details

Type

Article

Created At

09 Apr 2025