Gramme-positive bacteria were shown to be the primary cause of skin infections associated with diabetes, and they showed varying degrees of resistance to most antibiotics. Additionally, Vancomycin-resistant bacterial isolates were inhibited when a chloromazine minimal inhibitory concentration was employed in conjunction with vancomycin. Methodology and results: The current study isolated and identified the bacteria that cause skin infections in diabetic patients. Among the 20 swabs from the skin of diabetic patients, 11(55%) isolates grew and fermented the mannitol salt agar, 7(35%) of them coagulated the plasma in the coagulase test and were positive to catalase test and produced Beta haemolysis on blood agar. The resistance to antibiotics shows all (100%) isolates resistant to Benzylpenicillin and Oxacillin, 5 (71.5%) of isolates Staphylococcus aureus, resistant to Tetracycline, 4 (57%) isolates resistant to Erythromycin, 6 (85.7%) isolates resistant to Clindamycin, and 1 (14%) of isolates resistant to Fusidic acid, vancomycin, teicoplanin, and rifampicin, respectively.
Conclusion: According to the study, most skin ulcers in diabetic individuals are caused by gram-positive bacteria, which also exhibit multiple drug resistance. The combination of chlorpromazine and vancomycin also inhibited the bacterial resistance to the antibiotic, improving the likelihood that these ulcers could be treated. It is also advised that more research be done to determine how effective this medication is before applying it to human skin.