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The Impact of Multisystem Inflammatory Syndrome in Children Associated with COVID-19

Article

Last updated: 27 Apr 2025

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Subjects

-

Tags

Clinical microbiology

Abstract

Background: Multisystem Inflammatory Syndrome in Children (MIS-C) is a serious post-infectious complication associated with SARS-CoV-2 infection. Hyperinflammation and multi-organ dysfunction are hallmarks of MIS-C. MIS-C poses diagnostic and therapeutic challenges. Objective: The study intended to assess clinical and laboratory manifestations and severity predictors among MIS-C patients. Methodology: This retrospective study analysed data from 68 paediatric patients attained the paediatric intensive care unit (PICU) at Sohag University Hospital between September 2020 and August 2021. Based on laboratory confirmation of SARS-CoV-2 infection and WHO criteria, patients were allocated to the MIS-C group. Demographic and clinical data were collected, and laboratory parameters were compared between groups. Results: Of the 68 patients, 29 (42.6%) encountered the criteria for MIS-C. MIS-C cases were significantly older (median 9.4 vs. 3.4 years,) and heavier (median 36 vs. 15.5) than non-MIS-C patients. Fever, gastrointestinal symptoms (diarrhoea, vomiting, abdominal pain), and concurrent cardiac and renal dysfunction were predominant features in the MIS-C group. Laboratory analysis revealed significant elevations in inflammatory markers (CRP, ferritin, ESR), coagulation abnormalities (D-dimer, INR), and liver enzymes (ALT, AST) in MIS-C patients. Notably, TNF-α and IL-6 values did not considerably differ between the groups. Conclusions: This investigation emphasizes the multisystemic nature of MIS-C and highpoints the necessity of early recognition and proactive care. The lack of significant elevation in TNF-α and IL-6 suggests that alternative inflammatory pathways may be involved in MIS-C pathogenesis in this population.

DOI

10.21608/ejmm.2025.372442.1546

Keywords

COVID-19, Multisystem Inflammatory Syndrome, IL-6, TNF-α, paediatric intensive care unit

Authors

First Name

Alaa

Last Name

Barden

MiddleName

A.

Affiliation

Department of Clinical Pathology, Faculty of Medicine, Mansoura University, Mansoura, Egypt

Email

alaaaboelnoour@mans.edu.eg

City

-

Orcid

-

First Name

Eman

Last Name

Fahmy

MiddleName

M.

Affiliation

Department of Paediatrics, Faculty of Medicine, Sohag University, Sohag, Egypt

Email

ahmodiemad@yahoo.com

City

sohag

Orcid

-

First Name

Heba

Last Name

Ahmed

MiddleName

A.

Affiliation

Department of Clinical and Chemical Pathology, Faculty of Medicine, Sohag University, Sohag, Egypt

Email

hebaalkady@ymail.com

City

-

Orcid

0000-0002-5680-8610

First Name

Sherif M.

Last Name

El-kannishy

MiddleName

H.

Affiliation

Department of Toxicology, Mansoura Hospital, Faculty of Medicine, Mansoura University, Mansoura, Egypt

Email

drsherifelkhanishy@gmail.com

City

Cairo

Orcid

-

First Name

Sahar

Last Name

Aboulfotuh

MiddleName

-

Affiliation

Department of Clinical and Chemical Pathology, Faculty of Medicine, Sohag University, Sohag, Egypt

Email

abadran@horus.edu.eg

City

Sohag

Orcid

-

First Name

Noha

Last Name

Mahmoud

MiddleName

M.

Affiliation

Department of Medical Microbiology and Immunology, Faculty of Medicine, Mansoura University, Mansoura, Egypt

Email

nohamostafa_81@yahoo.com

City

mansoura

Orcid

https://orcid.org/00

First Name

Sara

Last Name

Essa

MiddleName

G.

Affiliation

Department of Clinical Pathology, Faculty of Medicine, Mansoura University, Mansoura, Egypt

Email

dr_saraghaleb@mans.edu.eg

City

mansoura

Orcid

-

Volume

34

Article Issue

3

Related Issue

53640

Issue Date

2025-07-01

Receive Date

2025-04-02

Publish Date

2025-07-01

Print ISSN

1110-2179

Online ISSN

2537-0979

Link

https://ejmm.journals.ekb.eg/article_421027.html

Detail API

http://journals.ekb.eg?_action=service&article_code=421027

Order

421,027

Type

New and original researches in the field of Microbiology.

Type Code

2,038

Publication Type

Journal

Publication Title

Egyptian Journal of Medical Microbiology

Publication Link

https://ejmm.journals.ekb.eg/

MainTitle

The Impact of Multisystem Inflammatory Syndrome in Children Associated with COVID-19

Details

Type

Article

Created At

09 Apr 2025