Objective: To evaluate the therapeutic effect of adding cabergoline

with letrozole in infertile women having (PCOS) with normal prolactin level.

Study design: A randomized controlled study.

Patients & methods: Infertile PCOS women with normal prolactin level

attending out patient clinic of obstetric &gynaecology department of

zagazig university & private clinic .

Those included( 200 ) patients randomly divided into two groups, each group(100) patients

group A,received letrozole plus cabergoline and group B recieved

letrozole.

Study design: for all patients , ultrasound on 2 nd day of

cycle then folliculometry after treatment detecting number,size of follicles ≥17mm with

endometrial thickness ,patients followed for one cycle.

The primary outcome was ovulation rate. The secondary

outcomes, clinical pregnancy r, miscarriage , multiple pregnancy

and ovarian hyperstimulation rate.

Results: 200 patients divided ( 100 in each group ). No statistical

difference between both groups in basal criteria. The

ovulation rate (group1) was 75% versus 60% (group 2) p-value 0.023* ,,Number of

dominant follicle ≥17mm significantly more in the same group

than in other ( p value 0.00**).

Stimulation days are less in group 1 than letrozole only group but no significance.

Patients in letrozole cabergoline group had a higher clinical pregnancy

rate reaching 27.0% versus 15.0 % in patients of the letrozole group (p-

value 0.037*)

No difference between both groups in miscarriage ,,multiple

gestation , ovarian hyperstimulation rate .

Conclusions: higher ovulation & clinical pregnancy rate with the

adding cabergoline with letrozole during ovulation induction in

euprolactinemic infertile pcos than use letrozole alone.