Background: Centered pregnancy model is the most well-known and evidence-based approach of group prenatal care which has been recognized to improve maternal and neonatal outcomes. Aim of research: The research aimed to investigate the effect of applying centered pregnancy model versus individual prenatal care on maternal and neonatal outcomes. Research design: A quasi-experimental (non-equivalent groups) research design was used to fulfill the aim of the study. Setting: The research was conducted at the obstetrics and gynecology outpatient clinic in Benha University Hospital. Sample: A purposive sample of 140 pregnant women divided randomly into centered pregnancy group comprised (70) women and individual prenatal care group comprised (70) women. Tools of data collection: Four tools were utilized for collecting data; a structured interviewing questionnaire, health promotion lifestyle profile-II, birth outcomes assessment sheet and patient participation and satisfaction questionnaire. Results: There was a statistically significant difference between centered pregnancy and individual prenatal care groups in relation to items of maternal and neonatal birth outcomes (P ≤ 0.05); there were lower rates of preterm labor and cesarean section delivery, shorter length of maternal hospital stay and early initiation of breast feeding. Also, decreased rates of low birth weight and neonatal admission to intensive care unit in centered pregnancy group compared with individual prenatal care group. Conclusion: Centered pregnancy model had a positive effect on improving health behaviors during pregnancy, positive maternal and neonatal outcomes as well as most of the women in centered pregnancy group had high participation and satisfaction with centered pregnancy model. Recommendation: Implementation of centered pregnancy model as a standard practice for improving maternal and neonatal outcomes.