Background: Bronchial asthma is reversible and diffuse airway inflammation. The inflammation leads to obstruction due to vascular congestion, mucosal edema, reducing the airway diameter and contraction of the bronchial smooth muscle that encircles the airways (bronchospasm), which causing further narrowing. Aim of the study: This study aimed to evaluate the effect of implementing educational guidelines on knowledge, practice and self-care management of patient with Bronchial Asthma. Research design: A Quasi-experimental research design. Setting: The study was carried out in the chest department at Benha University Hospital. Subjects: A purposive sample of (92 patients) undergoing bronchial asthma was recruited. Tools of data collection: Three tools were utilized: Tool (I): Patient structured interview questionnaire, Tool (II): Observational checklist for patients and Tool (III): Asthma Self-Management Questionnaire. Results: There was a significant improvement in total patients' knowledge score from (91.1%) unsatisfactory patients' knowledge score pre-educational guidelines implementation to (88.9%) and (83.3%) satisfactory patients' knowledge score post and follow-up of educational guidelines implementation. Also, there was a significant improvement in total patients' practices scores regarding bronchial asthma care from (90.0%) incompetent practice pre-educational guidelines implementation to (86.7%) and (80.0%) competent practice post and follow-up of educational guidelines implementation. Additionally, there was a significant improvement in total patients' self-care management from (86.6%) poor self-management pre-educational guidelines implementation to (88.9%) and (77.8%) good self-management post and follow-up of educational guidelines implementation. Conclusion: The educational guidelines were effective in improving patient's knowledge, practice and self-care management. Recommendations: Integrating counseling services into asthma clinics or healthcare settings to address the unique challenges faced by patients.