Background: Virtual simulation is an innovative approach to provide virtual clinical experiences through a digital platform where learners can complete specific tasks in various environments. Aim of the study: This study aimed to evaluate the effect of training virtual simulation skill on improving learning outcomes among nursing students. Research design: Experimental research design was used. Research setting: The study was conducted in the Medical Surgical Nursing Labs and Virtual Lab at Faculty of Nursing- Benha University, Egypt. Study subjects: The study included a systematic random sample of 229 medical surgical nursing students in first year/ second semesters throughout the academic year 2023–2024. Tools of data collection: Three tools were used; Tool I: A Structure students' questionnaire to assess students' knowledge, Tool II: Observational checklist to assess practice related to nasogastric tube insertion and Tool III: Students' class satisfaction measuring questionnaire. Results: The study revealed that 16.5% and 92.2% of the studied nursing students of traditional and virtual simulation groups had good level of total knowledge about nasogastric tube insertion and virtual simulation post one month (follow up) respectively. While, 81.6% and 62.1% of the studied nursing students of traditional and virtual simulation groups had competent level of total practice about nasogastric tube insertion at follow up. Also, 79.6% and 64.1% of the studied nursing students of traditional and virtual simulation groups had high satisfaction level at follow up of training. Conclusion: Virtual simulation skill showed its effectiveness in improving nursing students' knowledge, practice and satisfaction. Recommendation: Incorporating virtual simulation as an effective teaching strategy with traditional teaching in different nursing clinical courses to enhance nursing students' performance in clinical settings.