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Evaluation of PvuII (rs2234693) and AhR (rs2066853) Gene Polymorphisms‎ ‎as Prognostic Markers in Breast Cancer

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Last updated: 27 Apr 2025

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Clinical Research (Medical)

Abstract

Background: the most common cancer detected in females is ‎breast ‎cancer. Several genetic alterations may have prognostic effect on ‎breast ‎cancer. Single-nucleotide polymorphisms might predict breast ‎cancer ‎management. Single nucleotide polymorphisms of PvuII ‎‎(T/C ‎substitution) and aryl hydrocarbon (G/A substitution) were ‎estimated as ‎probable genetic prognostic factors for breast cancer. Aim: ‎to assess the ‎relation between estrogen receptor alpha PvuII (rs2234693) ‎and aryl ‎hydrocarbon receptor gene polymorphisms (rs2066853) in ‎breast cancer ‎prognosis. Material and method: this study is case-control ‎that ‎enrolled 120 breast cancer patients categorized into two groups: the ‎first ‎one involved 60 females with good prognostic factors, the second ‎group ‎included 60 females with poor prognostic factors. Genotyping ‎assay ‎were done by a real-time polymerase chain reaction. Results: our ‎finding ‎revealed that the allelic frequency of wild-type genotypes for ‎PvuII and ‎AhR polymorphisms was associated with patients who had ‎better ‎prognosis for breast cancer. Their mutant genotypes were ‎significantly ‎associated with poor prognoses in breast cancer patients. ‎Conclusion: ‎PvuII, AhR genotypes were statistically significant ‎associated with ‎breast cancer ‎ prognosis. ‎

DOI

10.21608/scumj.2024.421503

Keywords

Genetic factors, estrogen receptor, aryl hydrocarbon, prognosis

Authors

First Name

Sara

Last Name

Aboelroos

MiddleName

Abd EL-Monem

Affiliation

Department of Clinical Pathology, Faculty of Medicine, Suez Canal University, Egypt.

Email

sara.aboelros@yahoo.com

City

Ismalia

Orcid

Sara Aboelroos‎

First Name

Elsayed

Last Name

Eltamany

MiddleName

Hussein Mostafa

Affiliation

Department of Organic Chemistry, Faculty of Science, Suez Canal University, Egypt.

Email

s.eltamany51@yahoo.com

City

Ismalia

Orcid

‎Elsayed Hussein

First Name

Faten

Last Name

Mohamed

MiddleName

Abdelmonem Metwalli

Affiliation

Department of Biochemistry, Faculty of Science, Suez Canal University, Egypt.

Email

fatenabdulmonem@science.suez.edu.eg

City

Ismalia

Orcid

faten Abdelmonem

First Name

Marwa

Last Name

Suliman

MiddleName

Awad

Affiliation

Department of Clinical Oncology and Nuclear Medicine, Faculty of Medicine, Suez Canal University, Egypt.

Email

marwaawad2008@gmail.com

City

Ismalia

Orcid

‎Marwa Awad

Volume

27

Article Issue

6

Related Issue

52238

Issue Date

2024-06-01

Receive Date

2024-04-04

Publish Date

2024-06-01

Page Start

24

Page End

34

Print ISSN

1110-6999

Online ISSN

2090-2581

Article File

SCUMJ_Volume 27_Issue 6_Pages 24-34.pdf

PDF . 595.7kB

Link

https://scumj.journals.ekb.eg/article_421503.html

Detail API

http://journals.ekb.eg?_action=service&article_code=421503

Order

3

Type

Original Article

Type Code

938

Publication Type

Journal

Publication Title

Suez Canal University Medical Journal

Publication Link

https://scumj.journals.ekb.eg/

MainTitle

Evaluation of PvuII (rs2234693) and AhR (rs2066853) Gene Polymorphisms‎ ‎as Prognostic Markers in Breast Cancer

Details

Type

Article

Created At

09 Apr 2025