Osteoporosis in postmenopausal women is a significant health concern characterized by reduced bone mineral density and an increased risk of fractures. High-impact exercise serves as a potent non-pharmacological intervention, promoting osteogenic stimuli that enhance bone mass, improve bone architecture, and mitigate fracture risk by stimulating bone remodeling processes. Methodology: The current study aimed to evaluate the effectiveness of high-impact exercises on bone mineral density (BMD) and physical performance among postmenopausal women with osteoporosis. A quasi-experimental research design was utilized, conducted across five faculties affiliated with Kafr El-Sheikh University, Egypt. A purposive sample of 40 postmenopausal women was recruited from the aforementioned settings. The selected participants were assigned to two study groups (A & B). Data were collected using three tools: (1) a structured interview schedule to assess participants' baseline characteristics and clinical data, (2) Dual-Energy X-ray Absorptiometry (DEXA), and (3) the Osteoporosis Assessment Questionnaire-Physical Function (OPAQ-PF).Results: At baseline, DEXA measurements did not differ significantly between the two study groups (A & B). However, post-intervention, a marked improvement was observed in Group A, where the mean T-score improved to –1.28 ± 0.20 compared to –1.89 ± 0.18 in Group B. This difference was highly statistically significant (t = 10.086, p < 0.001). Additionally, the overall OPAQ-PF total score in Group A improved significantly to (72.00 ± 18.5) compared to Group B (60.00 ± 21.0) with a statistically significant difference among both groups (p < 0.004) post-intervention. Conclusion: The present study's findings indicate that treadmill walking represents a simple, cost-effective, and accessible intervention that can be incorporated into osteoporosis management programs to improve bone health and reduce fracture risk in postmenopausal women. Thus, the study's aim and hypothesis (H1) were supported within the framework of the present study. Recommendations: Healthcare practitioners should be encouraged to integrate high-impact weight-bearing exercises, such as treadmill walking, into standard osteoporosis care protocols for postmenopausal women.