Background: many studies reported an associated between ABO blood groups and COVID-19 susceptibility and disease severity. Materials and methods: The data was obtained from data records of Alyameny laboratory files in Alexandria city, Egypt, for 504 COVID-19 mildly infected patients were collected from data records in 3 years (2020- 2022), in Al-Raml District, Alexandria city, Egypt and compared with the prevalence distribution of blood groups in the same district in previous study. Results: This study showed that blood group A had the highest COVID-19 infection percentage (45.1%), and the infection of O, B, and AB blood groups was 22.6%, 21%, and 11.3%, respectively,  the COVID-19 infection susceptibility in blood group A > O> B> AB, also the blood group A had the highest distribution (32.4%), and the distribution of O, B, and AB blood groups was 31.8%, 25.3%, and 10.5%, respectively, blood group distribution in blood group A > O> B> AB in the same manner as the percentage of COVID 19 infection, so this research demonstrated there is no associations between ABO blood group and susceptibility to COVID-19 mild infection.
Conclusion: This research demonstrated there is no association between ABO blood group and susceptibility to COVID-19 mild infection, the relationship between blood group, COVID-19 infection, and disease susceptibility or severity is still under debate and not fully understood.