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Receptor Activator of Nuclear Factor Kappa-B Ligand and Presepsin as Crucial Biomarkers in Women with Rheumatoid Arthritis

Article

Last updated: 29 Mar 2025

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Tags

Clinical microbiology

Abstract

Background: Rheumatoid arthritis (RA) is a long-term autoimmune disorder that primarily targets the joints. It causes persistent inflammation, leading to pain, swelling, and gradual joint deterioration. Objective: This study investigates the immunological role of Receptor Activator of Nuclear Factor Kappa-B Ligand (RANKL) and presepsin in the blood of women with rheumatoid arthritis. Methodology: A case-control study was conducted at AL-Najaf Medical City, Iraq from October 2023 to February 2025. This study enrolled 60 healthy participants as a control group, 30 early RA women, 30 moderate RA Women, and 30 severe RA Women; all Women were diagnosed by the physician. RANKL and presepsin have been measured in women' blood using the ELISA technique. Results: The blood levels of RANKL (42.12±2.432 pg/ml) and presepsin (211.7±7.937 pg/ml) in all women were significantly higher than those in the control group (19.93 ± 1.416 pg/ml and 182.8 ± 14.51 pg/ml, respectively), with P-values of < 0.0001 and 0.0339. RANKL levels showed a significant increase (P < 0.05) in women with moderate and severe RA, while presepsin levels were significantly elevated (P < 0.0241) in women with severe RA compared to healthy controls. Additionally, a positive correlation was observed between the two markers in women with moderate and severe RA. Conclusion: RANKL and presepsin may be viable markers for diagnosing rheumatoid arthritis, and their raised levels may indicate disease severity. In addition, these biomarkers may be useful in the treatment of rheumatoid arthritis among women.

DOI

10.21608/ejmm.2025.368427.1522

Keywords

RANKL, presepsin, RA, Women, correlation

Authors

First Name

Alaa

Last Name

Abdul-Hussain

MiddleName

H.

Affiliation

Faculty of Medicine, Jabir ibn Hayyan University for Medical and Pharmaceutical Sciences

Email

alaa.h.abdulhussein@jmu.edu.iq

City

-

Orcid

-

First Name

ِAhmed

Last Name

Aljanaby

MiddleName

A.J.

Affiliation

University of Kufa, Faculty of Science, Department of Biology, Iraq

Email

ahmedjaloob@gmail.com

City

-

Orcid

-

Volume

34

Article Issue

4

Related Issue

54773

Issue Date

2025-10-01

Receive Date

2025-03-15

Publish Date

2025-10-01

Print ISSN

1110-2179

Online ISSN

2537-0979

Link

https://ejmm.journals.ekb.eg/article_419721.html

Detail API

http://journals.ekb.eg?_action=service&article_code=419721

Order

419,721

Type

New and original researches in the field of Microbiology.

Type Code

2,038

Publication Type

Journal

Publication Title

Egyptian Journal of Medical Microbiology

Publication Link

https://ejmm.journals.ekb.eg/

MainTitle

Receptor Activator of Nuclear Factor Kappa-B Ligand and Presepsin as Crucial Biomarkers in Women with Rheumatoid Arthritis

Details

Type

Article

Created At

29 Mar 2025