Mimusops genus, the most important and biggest genus of family Sapotaceae comprising of approximately 57 species, is native to tropical and subtropical regions of Asia, Africa, Australia, and various oceanic islands. Some species of which have been usually used in traditional medicine for thousands of years. Some species of this genus can also be used in green synthesis of gold and silver nanoparticles, dye industry for cotton and silk fabrics and other applications. The triterpenoid saponins, as one of the most important bioactive components of the Mimusops genus, have attracted the attention of the scientific community. Thus, a comprehensive and systematic review on triterpenoid saponins and triterpenoids/sterols from the genus is indispensable. In this review, a total of twenty-eight and thirty-seven triterpenoid saponins and triterpenoids/sterols respectively, from the genus Mimusops together with their pharmacological activities including anti-inflammatory, anti-oxidant, hepatoprotective, anti-bacterial, antiulcer, anti-cancer, cytotoxicity, anti-convulsion, anti-pyretic, anti plasmodial, antiurolithiatic and hypoglycemic effects were summarized.