Background: Lymphedema showed increased frequency all over the world. Globally, it affects > 100 million. It had unwanted impact on the patient lifestyle and productivity.
The aim of the work: This study aimed to assess the value of compression therapy for lymphedema of either upper or lower limbs regarding its safety and efficacy.  
Patients and Methods: This study included 100 patients [72 females, and lower limb affection reported for 86 patients, with bilateral inclusion in 6 patients], who had primary or secondary lymphedema affecting lower and/or upper limbs. They were selected from Al-Azhar university Hospital [Damietta]. The limb circumference was recorded at different fixed 3 points before and after compression therapy.  Before applications of bandaging, a local steroid combined with antifungal and antiseptics were applied over the affected lim.  Then a multilayer bandage was applied [it started by gauze, mobiderm, short stretch and finally elastic bandage with compression around 30 mmHg]. This was applied for one week. Then layers were removed [except the last one] and limb was evaluated clinically after removal and weekly for the next 3 weeks. The last layer was removed    during the time of bed rest at the last 3 weeks of compression therapy.
Results: The follow up duration was 1-2 months. The final clinical evaluation revealed marked and significant reduction the volume of the limb. In addition, the quality of life was improved for all patients. Furthermore, no significant complications were recorded. However, the final outcome indicated the need to wear a compression stocking.
Conclusion: Compression therapy for lymphedema of the lower or the upper limbs using multilayer bandage [by Mobiderm] could be considered as a cost-effective, fast and easily applied. It is association with resorption of lymphedema and quick improvement of fibrosed tissues.