Clinical medical research plays a vital role in advancing medical science and addressing incurable diseases, yet it must operate within the boundaries of human rights and ethical principles. This review explores the tension between the right to physical integrity and the societal need for medical progress. It examines international legal frameworks, including the Declaration of Helsinki and Egyptian Law No. 214 of 2020, which provide ethical and regulatory guidelines for conducting medical research. Key focus areas include informed consent, preclinical and clinical trial stages, and the integration of good clinical practices to ensure safety and efficacy. The study emphasizes the collaborative role of law and medicine in fostering innovation while safeguarding human dignity. It also underscores the importance of rigorous ethical oversight to reconcile individual rights with societal benefits. this idea will be explain in this paper The legal framework for practicing scientific experimentation on people in light of Egyptian Law No. 214 of 2020 and comparative legislation