Salinity is a major constraint for sustainable rice production. Developing new rice varieties with inherent tolerance against these major abiotic stresses will help increase rice production under unfavorable conditions. The present study was conducted to create abiotic stress-tolerant rice genotypes in the genetic background of the popular rice variety improved Giza179 by pyramid hybridization and SSR markers. The results showed that all the basic parents IR1515-31, BG94-2 AC1225, Hua Lien Yu 202, GZ1368-5-S-4, and GZ6296 contributed to producing the new variety Giza179. The analysis of variance showed highly significant differences for all the studied traits under saline soil conditions except root length and milling percentage. The main performance showed that the salinity conditions at the Lysimeter site negatively affected the yield trait for all rice genotypes compared with normal soil. The phenotypic coefficient of variability (PCV%) was greater than the genotypic coefficient of variability (GCV%) in all genotypes for all traits over two years. This means that most of the PCV% was influenced by environmental factors and cultural practices.  Twelve SSR markers were identified, and association analysis revealed that the markers RM1212, RM9, RM493, and RM23 had the highest PIC values.