The empowerment of staff nurses create a great professional satisfaction, declination in rates of burnout, and increasing in autonomy and organizational commitment. Furthermore, it has a positive effect on the standard of treatment and patient safety in the healthcare system. Aim: Determine the relationships between structural empowerment and patient safety culture among staff nurses in Fowa Central Hospital at Kafr ElSheikh. Methods: A descriptive correlational design was used and included 225 staff nurses working at Fowa Central Hospital at Kafr ElSheikh. Two tools were used to collect the data: Conditions of Work Effectiveness Questionnaire-II (CWEQ) and Patient Safety Culture Questionnaire. Results: 78.2% of nurses exhibited a moderate level of structure empowerment. Also, 99.1% of the nurses perceived a moderate level of overall patient safety culture. Conclusion: Structural empowerment has a significant influence on patient safety culture, because patient safety culture and structural empowerment showed a statistically meaningful relationship. Recommendations: nurse managers empowered their staff by providing opportunity to learn and grow, support, and necessary resources. Standardizing hand-off guidelines, as it contributes to developing a strong patient safety culture.