Background: One of the most important variables in determining how well staff nurses function and provide patients with care is emotional exhaustion. Aim: to assess the relationship between emotional exhaustion and job performance among staff nurses. Methods: A descriptive, correlational design was utilized with a sample of (165) staff nurses at Main Mansoura University hospital. The Job Performance Observation Checklist and the Emotional Exhaustion Questionnaire were the data gathering tools. Results: Of the staff nurses surveyed, 40.0% reported a low level of emotional exhaustion and 42.4% reported a moderate level of job performance. The results showed that there was a statistically significant negative correlation between emotional exhaustion and job performance. Conclusion: At Main Mansoura University Hospital, a statistically significant negative association was discovered between emotional exhaustion and job performance. Recommendations: Encourage a positive work environment that makes staff nurses feel secure and emotionally stable. Fostering a supportive work environment can increase staff nurses' sense of empowerment, confidence, and job performance. Provide regular training program to staff nurses for reinforcing their acquisition of communication skills, techniques and procedures of effective communication. Provide more flexible pay and incentive structures to boost the morale of nurses, enhance their work output, and ultimately raise the standard of healthcare.