Background: One of the most important aspects of high-quality healthcare is patient safety
and developing a patient safety culture was crucial to ensuring healthcare quality. Establishing a
patient safety culture is becoming increasingly important as medical organizations work to
improve the quality of care they provide. It is necessary for newly graduated nurses with less work
experience and teaming abilities to enhance their interpersonal and collaborative abilities in order
to advance the patient safety culture. Aim: To assess patient safety culture among newly graduate
nurses at Main Mansura University Hospital. Methods: A descriptive and cross-sectional design
was used in this study and the convenient sample was used that conducted on 132 newly graduated
nurses working in all departments at Main Mansoura University Hospital by using The Hospital
Survey on Patient Safety Culture (HSPSC). Results: More than half of newly graduated nurses
(70.5%) was negatively perceptions of patient safety culture. There was no statistically significant
relation between newly graduate nurses' perceptions of patient safety culture related to their
personal characteristics in all variables except in gender was highly statistically significant.
Conclusions: This study concluded that the patient safety culture was negatively perceptions by
the newly graduated nurses at Main Mansoura University Hospital. Recommendation: Improving
patient safety culture, the nursing managers and healthcare organizations should discussion and
provide additional training with the newly graduated nurses to changes in strategies to improve the
quality of care and promote safe care.