Background: Nurses' work environments have a significant influence on the quality of care they can deliver, as well as workforce retention. Understanding work environmental variables that need to be improved, such as safety, climate, and teamwork, could aid in the maintenance of a satisfying hospital environment, perhaps retaining talented nurses and increasing their desire to stay. The goal is to establish the association between the nurses' work environment and patient safety culture at Al Dawadmi General Hospital. Method: The descriptive correlational design was utilized in this investigation at Dawadmi General Hospital in Dawadmi, Saudi Arabia. A convenience sample of 281 available staff nurses will be included using two tools: Nursing Work Environment Scale, and Patient Safety Culture Scale. Results: Half of the study's staff nurses (47.7%) have average level of nursing work environment, 72.6% have average level of patient safety culture, and there is a highly statistically significant relationship between nurses' perception of staff nurses' work environment and patient safety culture (r= 0.74 / p=0.000**). Conclusion: It was determined that the nurse practice environment has a substantial impact on preserving patient safety culture. So, the current study confirmed that optimizing nursing practice environments could improve the patient safety culture by making care safer and reducing adverse events by providing as many resources and staffing as possible, encouraging participation in decision-making and teamwork, and offering appropriate incentives. Recommendation: An interventional effective patient safety program that incorporates it into health professional education should be continuously supported by health care providers across company.