Background: Venous thromboembolism (VTE) prevention considered as one of the patient safety priorities that need measuring and reporting considered. Aim of the study: This research serves as guide for providing principles for effective designing, implementing, and monitoring of VTE prevention programs for inpatients in secondary level care hospitals. Subjects and methods: Quantitative and qualitative study was used to design and develop quality improvement framework that develop a rubric VTE prevention program.. Results: The initial baseline assessment revealed suboptimal practice of VTE prevention. It followed by developing (1) documentation of a standardized VTE risk assessment upon admission (2) Local unified protocol and process map for assessing inpatients and prescription of optimal VTE prophylaxis. (3) Set of metrics were developed for monitoring purpose. It included the categories of measures needed to be collected with their specific collection time. Conclusion: Collaborative team efforts and supportive leadership were the cornerstone of development of successful standardized guidance for VTE risk assessment and prevention.