Background: Intensive care nurses' performance is defined, measured, and indicated by key performance indicators, which also help identify areas of weakness. The key performance indicators for intensive care is a clear performance metric used to track, evaluate, and improve all pertinent nursing care procedures for the highest quality of patient care. Aim: asses intensive care nurses' perception and practice regarding key performance indicators. Design: descriptive research design was used in the current study. Setting: the study was conducted at Tanta International Teaching Hospital. Subjects: All (120) registered nurses. Tools: Two tools were used; Tool I: Intensive Care Nurses' perception Questionnaire about key performance indicators, Tool II: Key Performance Indicators' observational checklist were used to collect the data. Results: none (0.0%) of the nurses had a high level of perception regarding Key performance indicators. Similarly, none (0.0%) of the nurses had a satisfactory level of overall practice regarding Key performance indicators. Conclusion: there was a statistically significant positive correlation between intensive care nurses' perception and their practice regarding key performance indicators. Recommendations: Periodically in-service training program was required enhance intensive care nurses' perception and practice regarding key performance indicators.