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418317

SITAGLIPTIN MITIGATES SCOPOLAMINE-INDUCED NEUROCOGNITIVE DEFICITS VIA ACTIVATION OF Nrf2/HO-1 PATHWAY AND IMPROVED MITOCHONDRIAL ACTIVITY

Article

Last updated: 29 Mar 2025

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Subjects

-

Tags

• Neuro Toxicology

Abstract

Background: Rats' memory is hampered by the muscarinic receptor antagonist scopolamine (Scop), which inhibits cholinergic neurotransmission. Objectives: to assess the protective impact of sitaglibtin and its underlying processes in neurocognitive impairments brought on by Scop. Methodology: Thirty adult male albino rats were divided into three groups: control, Scop, and Scop+STG (10/group). Rats were evaluated neurocognitively. The following were measured: BDNF, Nrf2, HO-1, citrate synthase (CS) activity, acetylcholine, MDA, SOD, TNF-α, interleukin (IL)-6, IL-10, and amyloid β 42 (Aβ42). Additionally, hippocampal histological and immunohistochemical analyses were performed. Results Along with significantly greater levels of MDA, TNF-α, IL-6, acetylcholine, and Aβ 42, as well as GFAP and Caspase-3 hippocampus immunoreaction, the Scop group also showed a decline in cognitive performance compared to control. Additionally, it down-regulated BDNF, Nrf2, and HO-1 gene expression in the hippocampus and markedly decreased IL-10, SOD, and CS activity. The Scop+STG showed a considerable amelioration in the neurocognitive deficits caused by Scop. Conclusion: In addition to up-regulating Nrf2 and HO-1 gene expressions, sitagliptin has a beneficial protective impact against Scop-induced cognition impairments through anti-oxidant, anti-inflammatory, enhanced mitochondrial activity, prevention of apoptosis, and neurotrophic actions.

DOI

10.21608/ejfsat.2024.335654.1355

Keywords

BDNF, Caspase-3, HO1, Nrf2, Scopolamine, Sitagliptin

Authors

First Name

suzan

Last Name

Khodir

MiddleName

A

Affiliation

physiology department, faculty of medicine, menoufia university

Email

suzan.abdalhameed.12@med.menofia.edu.eg

City

-

Orcid

-

First Name

Ahmad

Last Name

Gaafar

MiddleName

-

Affiliation

Medical Physiology Department, Faculty of Medicine, Menoufia University

Email

amrahmad2004@gmail.com

City

menoufia

Orcid

-

First Name

Basma

Last Name

Mostafa

MiddleName

-

Affiliation

Medical Biochemistry and Molecular Biology Department, Faculty of medicine, Menoufia University

Email

hashema877@yahoo.com

City

menoufia

Orcid

-

First Name

Noha

Last Name

Abd El-aziz

MiddleName

-

Affiliation

Anatomy and Embryology Department, Faculty of Medicine, Menoufia University

Email

rose_a.hashem256@yahoo.com

City

menoufia

Orcid

-

First Name

amany

Last Name

Elfakhrany

MiddleName

-

Affiliation

Clinical Pharmacology Department, Faculty of medicine, Menoufia University

Email

zahran_omar@ymail.com

City

menoufia

Orcid

-

First Name

Shehab

Last Name

Hassaan

MiddleName

-

Affiliation

Psychiatry department, Sulaiman Alrajhi University, Al Bukayriyah, Saudi Arabia. Psychiatry department, faculty of medicine, Assiut University, Assiut, Egypt.

Email

suzy25186@yahoo.com

City

-

Orcid

-

First Name

Mai

Last Name

Hassan

MiddleName

-

Affiliation

Anatomy and Embryology Department, Faculty of Medicine, Benha University

Email

suzy25186@gmail.com

City

menoufia

Orcid

-

First Name

Soha

Last Name

Abd EL-Khalek

MiddleName

-

Affiliation

Forensic Medicine and Clinical Toxicology department, Faculty of Medicine, Menoufia University

Email

d_sh_2007@yahoo.com

City

menoufia

Orcid

-

First Name

Menna Allah

Last Name

El Menyawi

MiddleName

-

Affiliation

Medical Physiology Department, Faculty of Medicine, Suez Canal University, Ismailia

Email

soso_egy89@yahoo.com

City

Ismailia

Orcid

-

Volume

25

Article Issue

1

Related Issue

54517

Issue Date

2025-03-01

Receive Date

2024-11-12

Publish Date

2025-03-01

Page Start

45

Page End

62

Print ISSN

1687-0875

Online ISSN

2535-1915

Article File

EJFSAT_Volume 25_Issue 1_Pages 45-62.pdf

PDF . 1.6MB

Link

https://ejfsat.journals.ekb.eg/article_418317.html

Detail API

http://journals.ekb.eg?_action=service&article_code=418317

Order

418,317

Type

Original Article

Type Code

429

Publication Type

Journal

Publication Title

The Egyptian Journal of Forensic Sciences and Applied Toxicology

Publication Link

https://ejfsat.journals.ekb.eg/

MainTitle

SITAGLIPTIN MITIGATES SCOPOLAMINE-INDUCED NEUROCOGNITIVE DEFICITS VIA ACTIVATION OF Nrf2/HO-1 PATHWAY AND IMPROVED MITOCHONDRIAL ACTIVITY

Details

Type

Article

Created At

29 Mar 2025