This study explores the combined effects of vermicompost application and Rhizobium inoculation on faba bean (Viciafaba L.) growth, nodulation, and yield over two successive winter seasons (2022/23 and 2023/24) in sandy soil at El-khatttara region, Sharkia Governorate, Egypt. Four levels of vermicompost (0, 1.5, 3.0, and 4.5 ton/fad.) and three inoculation treatments (uninoculated, Rhizobiumtropici, and Rhizobiumgallicum) were evaluated using a randomized complete block designin split plot arrangement with three replicates. Results demonstrated that the highest vermicompost level (4.5 ton/fad.) significantly increased the number of nodules per plant (up to 95.19 nodules on average) and dry nodule weight (up to 2.14 g in the second season). Rhizobiumtropici inoculation outperformed R. gallicum, with a 17.45% higher nodulation response and improved nitrogen fixation. Plant height increased by 41.19%, and branchs number per plant peaked at 5.31 under the combined application of 4.5 ton/fad.,vermicompost and R. tropici inoculation. Yield components showed remarkable improvements: the highest average of number of pods (39.65 pods/plant), seeds per pod (5.90), and 100-seed weight (92.43 g) were achieved under the same treatment combination. Biological yield reached 5.98 ton/fad., while seed and straw yields were 2.52 and 2.36 ton/fad, respectively, representing over a 30% increase compared to control treatment. Total nitrogen uptake and protein yield were also maximized at 132.5 kg/fad and 431.39 kg/fad., respectively, under these treatment. The study highlights the synergistic benefits of combining organic amendments and microbial inoculants, promoting sustainable faba bean production with enhanced nitrogen uptake, protein content and soil fertility.