Aim: This in vivo study aimed to evaluate the marginal and internal adaptation of endo-crown restorations made using various impression procedures using clinical and cone beam (CBCT). Materials and Methods: Forty Patients with endodontically treated lower first molar were chosen for this research from the Fixed Prosthodontics clinic at Tanta University's Faculty of Dentistry. 2 mm occlusal reduction, axial preparation with 7-degree total occlusal divergence with 3 mm pulpal floor depth were made to all teeth. Each specimen was randomly assigned to one of two groups: the group I served as the control which received endo-crown restorations made by conventional impression. The other group (group II) received restorations made by digital impression. After one week of cementation of Vita Enamic endo-crowns to specimens, internal adaptation was evaluated using CBCT. USPHS criteria were evaluated at baseline ,6 months and 1year. Independent t-test and Chi-square test were used for statistical analysis once data was collected, collated, and organized. Results: Regarding the internal adaptation measurements, group II has higher statistically significant internal adaptation than group I (P=0.000). Regarding marginal adaptation evaluation, a significant difference between both groups was found in favor of group II, p=0.008 after 6 months while p=0.037 after one year.                                                                  Conclusion: Impression techniques for Vita Enamic endo-crown fabrication affects marginal and internal adaptation to natural prepared tooth. Digital impression technique is highly recommended to be used during impression taking for endo-crowns rather than conventional impression.